Growing Antibiotic resistance and UTIs

Antibiotics are used to treat certain types of bacterial infection by killing bacteria or preventing them from spreading, however, antibiotics do not work for everything. Bacteria have discovered the mechanism to be resistant to antibiotics and these resistances are continuously growing. Urinary tract infections (UTIs) until recently were mainly non-severe infections. Now, standard antibiotics used to treat UTIs are increasingly not working. Considering their prevalence, UTI antibiotic resistance is a serious health issue worldwide.

UTIs are mainly due to Escheirichia coli (Ec). Ec is a bacteria present in the bowel. From there they invade the urinary bladder producing UTIs. The mechanism of infection has been very well studied and it is mainly due to its capacity to adhere to the inner wall of the urinary bladder thanks to their fimbria. Until now, antibiotics are often prescribed to kill Ec and to stop the UTI particularly for women that suffer recurrent problems.

Unfortunately, Ec is now sometimes resistant to antibiotics and this is becoming a serious problem-particularly for people suffering the misery of recurrent UTIs and cystitis.

Cystitis and urinary tract infections often referred to as UTIs, are reported as the most common types of bacterial infection in outpatient medicine- causing between 1 – 3% of all doctor visits. At a time when people are trying to avoid unnecessary trips is there anything to stop this often-recurrent problem?

Preventing Recurrent Infections Naturally – There are many potential triggers for uncomplicated recurrent bacterial cystitis: age, decreased mobility, and the menopause, and sexual activity, physical and genetic disposition. Anything that helps to avoid or dislodge the infection causing e coli is beneficial. Keeping well hydrated, good hygiene, weight control- and improving health, in general, will help fight off potential re-infection. However, recurrent infections will have damaged the bladder wall making it easier for the e coli to adhere to the bladder wall.

The most commonly prescribed treatment for prevention is the continuous ingestion of sub-therapeutic doses of antibiotics for up to three months, or sometimes even more. However, it has been found that repeated doses of antibiotics to control recurrence, although usually effective initially, can encourage the bacteria to become antibiotic-resistant. Furthermore, taking continuous antibiotics can cause other problems like intolerances, allergies and gut problems.

Stopping the adhesion of the e coli and dislodging it from the bladder wall is the key to success.

Evidence suggests that substances known as proanthocyanidins, which are found in cranberries, may interfere with the adhesion of bacteria (particularly E. coli) to the walls of the urinary tract.

Cranberry products vary widely in their chemical composition and thus their effectiveness.

The main mechanism of action is the inhibition of the bacterial adherence to uroepithelial cells and Pac’s are identified as responsible for this action. Pac’s have been proven to be dose-dependent for their efficacy. So it’s important to choose a product proven to have an anti-adhesive effect on e coli.

Cysticlean 240mg PAC has the highest PAC content available on the market which makes it THE product for natural lasting urinary comfort, helping sufferers to reduce long-term antibiotic use. A natural product from a company that has invested heavily in research of the benefits of PAC from cranberry extract.

Now available with Cysticlean®240mg PAC D mannose in a sachet form-ideal where this has been recommended, or for people that prefer to take in a liquid form.

More information can be found on the Cysticlean website.

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